Chronic Allograft Nephropathy, abbreviated CAN, is characterized by a gradual loss of kidney function after the transplantation. CAN happens month to years after the transplantation is done.
The exact cause of this disease is unknown until now. But clinically, we could tell by some of its symptoms, such as slowly declined kidney function, accompanied with progressive proteinuria and high blood pressure. The result of Chronic Allograft Nephropathy is renal ischemia, hypertension, tubular atrophy, interstitial fibrosis, and glomerular atrophy with Renal Failure.
Risk factors
▪ Immunological factor
Barely satisfactory match of human leukocyte antigen is regarded as one of the most vital risk factors affecting further transplanted kidney function.
▪ Quality of transplanted kidney
Age, gender, physical health and DGF (delayed graft function), brain dead, the kidney's preservation and many some other factors could possibly affect the quality of transplanted kidney and of course, determines the CAN in some extent.
▪ Non-immunological factors
Application of nerve calcium protein antagonist
Cytomegalovirus infection
High blood fat
High blood pressure
proteinuria
Prognosis
The prognosis of Chronic Allograft Nephropathy is hard to manage since the occurrence of CAN indicates irreversible renal damages. The treatments could just protect remaining nephrons as much as possible, but couldn't correct the condition as it becomes. https://healthyonyours.com/
Prevention
Improve the quality of kidneys
Minimize the match mistakes of human leukocyte antigen between donor and recipient
Closely monitor acute rejection and deliver timely treatment
Keep an eye open for the infections
Take good control of high blood pressure and high blood fat
Limit the consumption of high protein foods
Deal with proteinuria as early as possible
